邓琛

     邓琛，讲师，工学博士，2022年毕业于江南大学生物工程学院，同年加入华东理工大学生物工程学院。研究领域代谢工程、合成生物学、酶学与酶工程、发酵工程等。通过转运途径改造、模块化代谢工程策略和动态基因调控等策略对代谢网络进行系统改造，构建了系列功能糖及生物基单体的微生物合成细胞工厂，高效合成化学品、蛋白质、生物材料及酶制剂。在相关领域以第一作者或通讯身份发表学术论文10余篇，获授权专利10余件，部分成果正在相关企业实施产业化。主持国家自然科学基金青年科学基金项目，国家重点研发计划重点专项子课题等多个项目或基金，获上海市科技进步一等奖（9/12）。

研究方向

· 功能糖的绿色生物合成

· 生物基材料化学品的绿色生物合成

· 光控动态调控基因回路的设计与构建

· 谷氨酸棒杆菌、假单胞菌的基因编辑及调控工具开发

主要承担科研项目

· 2023年上海市“晨光计划”

· 2023年国家自然科学基金青年项目

· 2022年国家重点研发计划重点专项子课题

代表性学术成果

1.Chen Deng, Ruijie Xin, Xingjian Li, Jie Zhang, Liqiang Fan, Yongjun Qiu, Liming Zhao*.Optogenetic control of Corynebacterium glutamicumgene expression. Nucleic Acids Research. 2024.11

2.Yanan Cui^#, Chen Deng^#, Liqiang Fan, Yongjun Qiu, Liming Zhao*, Progress in the biosynthesis of bio-based PET and PEF polyester monomers. Green Chemistry. 2023.10

3.Chen Deng, Mengxuan Zhao, Qiong Zhao, Liming Zhao*， Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides. Carbohydrate Polymers. 2023.03

4.Chunyu Ma, Chunyue Zhang, Liqiang Fan, Chen Deng*, Liming Zhao*,De novo 2′-fucosyllactose bioproduction through modular engineering of a novel Escherichia coliK12-derived strain. Food Bioengineering.2023.09

5.Chen Deng, Yaokang Wu, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Jian Chen, Long Liu*. Refactoring transcription factors for metabolic engineering. Biotechnology Advances. 2022.08

6.Chen Deng, Xueqin Lv, Jianghua Li, Hongzhi Zhang, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors.  Metabolic Engineering. 2021.07

7.Jiangong Lu, Yaokang Wu, Chen Deng, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu*, Model-based dynamic engineering of Escherichia coli for N-acetylglucosamine overproduction. Biotechnol Notes. 2022.02

8.Meng Chai, Chen Deng, Qi Chen, Wei Lu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu*. Synthetic Biology Toolkits and Metabolic Engineering Applied in Corynebacterium glutamicum for Biomanufacturing. ACS Synthetic Biology. 2021.12

9.Qiong Zhao, Liqiang Fan, Chen Deng, Chunyu Ma, Chunyue Zhang*, Liming Zhao*, Bioconversion of chitin into chitin oligosaccharides using a novel chitinase with high chitin-binding capacity. International journal of biological macromolecules. 2023.06

10.Jinqi Shi, Chen Deng, Chunyue Zhang, Shu Quan, Liqiang Fan*, Liming Zhao*, Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides. Synthetic and Systems Biotechnology. 2024.05

11.Chen Deng, Xueqin Lv, Jianghua Li, Hongzhi Zhang, Yanfeng Liu , Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors.  Metabolic Engineering. 2021.07

12.Chen Deng , Xueqin Lv , Jianghua Li , Yanfeng Liu, Guocheng Du, Long Liu*. Development of a DNA double-strand break-free base editing tool in Corynebacterium glutamicum for genome editing and metabolic engineering.  Metabolic Engineering Communications. 2020.12

13.Chen Deng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Wei Lu, Guocheng Du, Long Liu*. Metabolic engineering of Corynebacterium glutamicum S9114 based on whole-genome sequencing for efficient N-acetylglucosamine synthesis.  Synthetic and Systems Biotechnology. 2019.06

14.Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells.  Biotechnology and Bioengineering. 2019.01 (封面文章)

15.Chen Deng, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu*. Efficient expression of cyclodextrin glycosyltransferase from Geobacillus stearothermophilus in Escherichia coli by promoter engineering and downstream box evolution.  Journal of Biotechnology.2018.01  

学术荣誉

2022年度上海市“超级博士后”

国内外学术兼职

《Food Bioengineering》期刊编辑  

联系方式

通讯地址：上海市徐汇区梅陇路130号

邮编：200237

E-mail: chendeng@ecust.edu.cn